Click below for summaries of recent publications from Fondation Leducq-supported research.
Peripartum cardiomyopathy (PPCM) is characterized by acute heart failure late in pregnancy or early in the postpartum period.
Heart failure is defined as the inability of the heart to supply adequate blood flow to meet the body’s needs.
Cell size is determined by the balance of positively and negatively charged ions and other solutes in the fluids inside and outside cells.
The mitral valve, which separates the left atrium from the left ventricle, is composed of two leaflets attached to papillary muscles in the left ventricle.
Atrial fibrillation (AF) is characterized by rapid, irregular, unsynchronized contractions of the atria, the top chambers of the heart.
Dr. Kenneth Chien, North American coordinator of the Heart Progenitors in Cardiovascular Disease and Development network, and colleagues have identified a master cell in the developing human heart.
Duchenne muscular dystrophy (DMD) is an X-linked disorder affecting 1 in 3,500 males characterized by progressive muscle weakness and death by age 30 to 40 due to cardiac or respiratory failure.
Sudden cardiac death (SCD), which results from abnormal cardiac rhythms, accounts for more than half of all cardiovascular deaths in the United States.
A single nucleotide polymorphism (SNP), or genetic variation, in the chromosome 9p21.3 region has recently been found to be strongly associated with coronary artery disease.
Heart attacks are currently diagnosed based on blood tests that detect proteins that leak from injured heart muscle cells.
Fondation Leducq-supported researchers in Iowa and France have identified a gene variant that causes a common heart rhythm disorder called “sinus node dysfunction.”