Leducq Transatlantic Network on therapeutic arteriogenesis and metabolism modulation

European Coordinator:
  • Peter CARMELIET, Catholic University of Leuven (Belgium)
North American Coordinator:
  • Michael SIMONS, Yale University, New Haven (USA)
  • Anne EICHMANN, INSERM U833, Collège de France, Paris (France)
  • Luisa IRUELA-ARISPE, University of California, Los Angeles (USA)
  • Holger GERHARDT, London Research Institute-Cancer Research UK (UK)
  • Stefania NICIOLI, Yale University School of Medicine, New Haven (USA)
  • Michael POTENTE, Max-Planck-Institute for Heart and Lung Research, Bad Neuheim (Germany)

The narrowing of blood vessels by atherosclerosis results in a mismatch between the blood supply and the metabolic demands of the tissue supplied by the diseased vessels.  With progressive restriction of blood flow, the affected tissue becomes weaker and less able to function (ischemia).  Potential strategies to preserve tissue function include generation of new blood vessels and manipulation of the tissue’s metabolic demand and its tolerance of low oxygen levels (hypoxia).

This network will study four fundamental aspects of arteriogenesis, the formation of new arterial vessels:  guidance, development, maturation, and maintenance.  In parallel, the investigators will determine the pathways regulating tissue tolerance of hypoxia.  This network unites experts in cardiac, skeletal muscle, brain, and retina models of ischemia, as well as in gene therapy, to take an original approach toward ischemic disease.  Ultimately, the insight gained will be applied toward the development of novel therapies for patients with atherosclerosis.