Funded Networks

The Transatlantic Networks of Excellence Program grant recipients are listed below by year, project title and principal coordinators. For information about each network, please click below:



    1. Cellular and Molecular Targets to Promote Therapeutic Cardiac Regeneration
      David SASSOON, UPMC, Paris 
      Toren FINKEL, NIH, Bethesda 
    2. MicroRNA-based Therapeutic Strategies in Vascular Disease (MIRVAD)
      Thomas THUM, Hannover Medical School
      William SESSA, Yale University, New Haven 
    3. The function and regulation of PCSK9: a novel modulator of LDLR activity
      Nabil SEIDAH, Clinical Research Institute of Montreal
      Anders HAMSTEN, Karolinska Institute, Sweden
    4. Mechanical Triggers to Programmed Cell Death in Cardiomyocytes – and how to prevent their Action in Failing Hearts
      Siegfried LABEIT, University of Heidelberg
      Hendrikus GRANZIER, University of Arizona


    1. Pathogenesis of Small vessel Disease of the Brain
      Anne JOUTEL, INSERM, Paris 7
      Mark T. NELSON, University of Vermont, Burlington
    2. Understanding coronary artery disease genes
      A. Jake LUSIS, University of California; Los Angeles
      Heribert SCHUNKERT, University of Lübeck
    3. MIBAVA-Mechanistic Interrogation of Bicuspid Aortic Valve associated Aortopathy
      Bart LOEYS, University of Antwerp
      Harry DIETZ, John Hopkins University, Baltimore
    4. TNT-Triglyceride Metabolism in Obesity and Cardiovascular Disease
      Rudolf ZECHNER, University of Graz
      Stephen G. YOUNG, UCLA, Los Angeles


    1. Genomic, epigenomic and systems dissection of mechanisms underlying dilated cardiomyopathy
      Christine SEIDMAN, Harvard Medical School, Boston
      Stuart COOK, Imperial College Faculty of Medicine, London
    2. Translating human pluripotent stem cells from heart disease models to cardiac repair
      Michel PUCEAT, Université Paris Descartes, INSERM U633, Evry
      Andre TERZIC, Mayo Clinic, Rochester
    3. Lymph vessels in obesity and cardiovascular disease
      Kari ALITALO, University of Helsinki
      Mark KAHN, University of Pennsylvania, Philadelphia
    4. Proteotoxicity:  an unappreciated mechanism of heart disease and its potential for novel therapeutics
      Jeffrey ROBBINS, Cincinnati Children's Hospital
      Mathias GAUTEL, King's College, London


    1. Transatlantic Network on newborn stroke:  inflammatory modulation of neurovascular injury
      Pierre GRESSENS, Hôpital Robert Debré, INSERM U676, Paris
      Donna FERRIERO, University of California, San Francisco
    2. Multidisciplinary program to elucidate the role of bone morphogenetic protein signaling in the pathogenesis of pulmonary and systemic vascular diseases   Kenneth BLOCH, Harvard Medical School, Boston
      Nicholas MORRELL, University of Cambridge
    3. Molecular mechanisms of novel genes associated with plasma lipids and cardiovascular disease
      Daniel RADER, University of Pennsylvania, Philadelphia
      Christian WEBER, RWTH Aachen University
    4. High-density lipoprotein dysfunction in the development of cardiovascular disease and as a therapeutic target
      Thomas LUSCHER, University of Zurich
      Alan FOGELMAN, University of California, Los Angeles


    1. Redox and nitrosative regulation of cardiac remodeling:  novel therapeutic approaches for heart failure 
      Ajay SHAH, King's College, London
      David KASS, Johns Hopkins University, Baltimore
    2. Leducq Transatlantic Network on therapeutic arteriogenesis and metabolism modulation
      Michael SIMONS, Yale University, New Haven
      Peter CARMELIET, Catholic University of Leuven
    3. Structural alterations in the myocardium and the substrate for cardiac fibrillation 
      Jose JALIFE, University of Michigan, Ann Arbor
      Stéphane HATEM, Université Pierre Marie Curie, Paris
    4. Multi-scale modeling of single ventricle hearts for clinical decision support
      Tain-Yen HSIA, Great Ormond Street Hospital for Children, London
      Richard FIGLIOLA, Clemson University


    1. Alliance for Calmodulin Kinase II Signaling in Heart Failure and Arrhythmias
      Mark E. ANDERSON, University of Iowa, Iowa City
      Silvia G. PRIORI, University of Pavia
    2. Mechanisms matching the brain's vascular energy supply to neural activity, and their disruption after stroke
      Brian MacVICAR, University of British Columbia, Vancouver
      David ATTWELL, University College, London
    3. MicroRNAs as therapeutic targets in heart failure
      Eric N. OLSON, University of Texas Southwestern Medical Center, Dallas
      Stefan ENGELHARDT, Technische Universität München


    1. Transatlantic Network on Hypertension – Renal Salt Handling in the Control of Blood Pressure
      Steven C. HEBERT (†15/04/2008)/Richard LIFTON, Yale University School of Medicine, New Haven
      Bernard C. ROSSIER, University of Lausanne
    2. Transatlantic Network of Excellence for the Identification of Novel Genetic Targets in Hemorrhagic Stroke
      Elisabetta DEJANA, Institute for Molecular Oncology Foundation, Milan
      Brant WEINSTEIN, National Institutes of Health, Bethesda
    3. European-North American Atrial Fibrillation Research Alliance (ENAFRA)
      Dobromir DOBREV, University of Heidelberg, Mannheim
      Stanley NATTEL, Montreal Heart Institute
    4. Mitral Valve Disease: From Genetic Mechanisms to Improved Repair
      Robert A. LEVINE, Massachusetts General Hospital, Boston
      Albert A. HAGÈGE, Hôpital Européen Georges Pompidou, Paris







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